Changing prevalence of aetiological factors and comorbidities among Australians hospitalised for cirrhosis

Background The rate of hospital admissions for cirrhosis increased 1.3-fold during 2008–2016 in Queensland. Alcohol misuse was a contributing factor 55% and 40% patients had at least one comorbidity. Aims To examine the temporal change aetiology liver disease presence comorbidity admitted with cirrhosis. Methods Population-based retrospective cohort study all people treated (10 254 patients) Queensland 2008–2016. Data were sourced from Hospital Admitted Patient Collection. Results commonest alcohol (49.5%), followed by cryptogenic (unspecified cirrhosis; 28.5%), hepatitis C virus (19.3%), non-alcoholic fatty (NAFLD)/non-alcoholic steatohepatitis (NASH) (4.8%) B (HBV) (4.3%). prevalence alcohol-related (P = 0.41) 0.08) remained stable between 2008–2010 2014–2016, that NAFLD/NASH, HBV-cirrhosis 67% < 0.00001), 27% 0.00001) 20% 0.00019), respectively; 41.1% type 2 diabetes nearly doubled (from 13.7% to 25.4%; P 2014–2016. Conclusions most important aetiology. importance burden Ongoing increasing comorbid among has implications public health interventions reduce unhealthy lifestyle metabolic disorders.